منابع مشابه
Inhaled corticosteroids in asthma management.
Asthma is a disorder of the lower airways, characterized by bronchial hyperresponsiveness and airflow limitation, the pathogenesis of which is yet to be fully understood. Regardless of its triggers, asthma's hallmark is a state of inflammation that, when uncontrolled, results in persistence of symptoms. Inhaled corticosteroids are established as the mainstay of asthma therapy. This paper examin...
متن کاملModerate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma.
BACKGROUND There is uncertainty as to the dose of inhaled corticosteroids (ICS) at which to start concomitant long acting beta agonist (LABA) treatment in patients with asthma not adequately controlled by ICS alone. METHODS A meta-analysis was carried out of randomised, double blind clinical trials that compared the efficacy of adding salmeterol to moderate doses of ICS (fluticasone propionat...
متن کاملAdrenal function and high dose inhaled corticosteroids for asthma.
OBJECTIVE To investigate effects on adrenal function of fluticasone, a recently released inhaled steroid preparation with lower systemic bioavailability than beclomethasone dipropionate. METHODS 34 children on high doses (400-909 micrograms/m2/d) of inhaled beclomethasone dipropionate or budesonide were recruited into a double blind, crossover study investigating the effects on adrenal functi...
متن کاملInhaled corticosteroids and long term outcome in adults with asthma.
The concept that treatment with inhaled corticosteroids (ICS) may improve long term lung function by reversing or minimising the effects of airway remodelling remains an attractive one but, until now, unproven. It is therefore with much interest that we read the publications of two observational studies by Lange et al and by Dijkstra et al. Both groups of authors hypothesised that asthmatic ind...
متن کاملRelevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma.
The pharmacokinetic and pharmacodynamic effects of inhaled corticosteroids (ICS) have shaped the efficacy and safety of these agents in the treatment of asthma. Important pharmacokinetic and pharmacodynamic characteristics that can enhance the efficacy of ICS include small particle size, high glucocorticoid-receptor-binding affinity, long pulmonary residence time and lipid conjugation. These ch...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2019
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201907-1301le